It can come with its own set of risks. Hoping all is ok. Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. did east germany have money? This occurs about 1 in every 150-200 samples. 20062023 BabyCenter, LLC, a Ziff Davis company. why is my nipt test inconclusive. Molecular tests also check for certain changes in a gene or chromosome that may cause or affect the chance of developing a specific disease or disorder, such as cancer. how to find the length of an oval track; how long to cook baked potato on grill; george pearsons house; distance from thunder bay to manitoba border I'm due 1/2015 and AMA (38). In approximately 1% of women, the NIPT result is unable to provide an assessment about one or more of the disorders being screened, or cannot provide an assessment of fetal sex. She should hopefully have a happy healthy baby now.. Hi guys, currently in the same boat. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. The user and all related content has been deleted. What if NIPT cannot make an assessment? Your test result shows that your pregnancy is at low risk for these three conditions. Every sample from a patient is tested to determine whether there is sufficient feto-placental DNA to provide a reliable result. Some radiologists like to comment on ALL the scans the technicians provided even the poor quality ones. to help the technology advance more with this newer test. Find advice, support and good company (and some stuff just for fun). I'm wondering if because I'm a plus size mother? Acosta decided to take advantage of non-invasive pregnancy testing, or NIPT, a relatively new prenatal screening method. Here are 3 factors that can lead to such a result. In most cases, the results will say that a genetic condition is unlikely. It happened to me with my blood results from the triple screening. Confirmed by amnio a week later. I believe the odds of retest are actually 5%? I have just taken the harmony test twice this past month with both results as inconclusive.. Inconclusive Panorama DNA test results! Please contact the moderators of this subreddit if you have any questions or concerns. Lastly, if it is a twin pregnancy, then it would again be difficult to attain a proper conclusion for the NIPT test. If the concentration of fetal DNA is below this, then the test might prove to be inconclusive. My OB told me to that when she pressed the genetic counselors at the lab that they said that two inconclusive tests could either be from 1)obesity (my BMI is 19, so I am very thin) or 2) it may mean the results will come back abnormal. To complete all the standard tests which came back fine and were able to identify that it was a boy but again, suspect maternal abmormality involving X chromosomes. They did not recommend further evaluation or testing with him. Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. Thank you for sharing, as the Natera Panorama has really freaked me out. The company I went with uses harmony test. I am overweight so that may be a contributing factor, although my OB was still very very surprised since she has had very few patients of any size receive an inconclusive result. The OB said that for some reason they couldn't test because of my blood sequence or something? I hope this helps. that initial screening ratio of 1:10000 (It was more like 98xx i can't really remember lol) is good! NIPT is most often used to screen for trisomy. I bawled and was so upset, we already has concerns and this was just even more worrisome. This time they are sending me to a high risk doctor. NIPT differs from conventional prenatal screening methods in two important ways. They need 4% (DNA?) I'm waiting on my nipt test results now too. Hopefully will have before weds next week. I just wanted to doit for the extra accuracy and seems like a bonus to also find out the gender! Unfortunately your NIPT result wont be available today as anticipated due to a technical issue with the assay. During pregnancy, opting for a non-invasive prenatal test has become the norm. Sources from your great-grandmother to the internet offer tales about how you tell the sex of your baby. NIPT is commonly used for chromosomal disorders that are caused by the presence of an extra (triploidy) or missing copy (aneuploidy) of a chromosome. Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. What to Expect has thousands of open discussions happening each day. Has someone fallen into such situation? Fingers crossed your 12 week scan comes back ok. A failed test result will only be reported after testing of both samples) Inconclusive result. If that is all normal I wouldnt worry about this. Just waiting for the office to call back to rebook. 16 week ultrasound scheduled for Monday, June 6 and Amniocentesis scheduled for Wednesday, June 8. What the heck, now so stressed! Hope you're doing OK. I just got referred to McMaster as well with a high risk FTS scan/blood work. Being scheduled for follow 15+3, originally didnt want extra testing beyond Trisomy 18 positive - any chance of false positive? I have been a wreck and don't know what to do or why this is happening.. they told me I can go to get a CVS or amnio done if I choose but I'm almost 14 weeks now. I'm so sorry to hear about your first trimester screening. We are Australias largest private genetics referral laboratory. Why should I choose Sonic to perform my NIPT? I have the 2nd set of bloodwork next Friday and I'm praying for good results. Just pooping in about the initial ratio1:10000 is fabulous! Makes me worried about why they can't pick up enough fetal DNA. unfortunately, I called the company and they won't give me any information! I got the results yesterday and another inconclusive. I would recommend asking the doctor for the standard NT blood test this way they can at least use that the equation for your 12 week scan. . This is unlikely to be a lab mistake. My fetal fraction on 2nd try was only 2.7% :( 3.8% sounds good! Its 100% accurate (I believe). Analysis of genes involved in drug metabolism and hypersensitivity, allowing clinicians to prescribe with confidence. I just retested yesterday since the company doesn't charge if it comes back inconclusive. May 2016. Possible reasons for this include: Timing of blood draw - there is a higher chance for the test to fail when the blood draw is done too early in the pregnancy, So sorry youre having to deal with this, and having to sit with this anxiety a bit longer. GAH! Note that once you confirm, this action cannot be undone. The performance of NIPT is affected by several factors including maternal obesity, which results in a greater rate of no-calls for obese pregnant women. A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. She actually specifically said that it didn't mean anything, bad or good. Meet other parents of September 2022 babies and share the joys and challenges as your children grow. Pregnancy. Their reasoning is that it affects their accuracy numbersand they don't want to skid away from the 99%. I could have written this myself. Why genetic testing is bad? As of now I have no cardiac or kidney problems but I will see specialists when this baby is born just to be sure. Results in some cases may return inconclusive or uncertain. Although I do have a very high BMI and am aware that this can cause inconclusive NIPT results too. Interpreting non-invasive prenatal test (NIPT) results. Luckily, my insurance covered both. Why Genetic testing is bad? I met with a genetic counsellor who reviewed my file, age and risk, nd we decided together no further testing was needdd however for peace of mind and funsies we did the quad test which is a hormone test and can flag for trisonmies. Often Sorry to bump an old post, but I am wondering if any of you ladies had the option to do both NIPT (Harmony) and NT? Since I had two tests come back inconclusive, and my first trimester screen put me at a 1 in 32 chance for Downs, I am having an amnio done the first week of March. The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. Run by research scientists who are experts in human DNA diagnostics, we also offer express shipping services to reduce waiting time. I was 11 weeks and 2 days when my blood was drawn. I think in my case, my first test must have been borderline. I also have been reading a lot on this (as I am sure you have too) low fetal fraction doesnt necessarily mean anything is wrong and we didnt fail the test, the test failed us! Update: my redraw came back low risk for everything! Genetic tests are frequently not covered by Medicare or private health insurance, Every sample from a patient is tested to determine whether there is sufficient feto-placental DNA to provide a reliable result. Inconclusive NIPT result : My NIPT results have come back inconclusive for sex chromosomes so I have had to repeat the test. But I wish you all the best! Had my harmony test at 10 weeks 3 days. There are 2 main sticky posts about what NIPT is, how it works, what it can miss and how false positives happen, sono findings, and your chances of a true positive after NIPT. We are repeating the assay on the same sample you have already sent and we should have that result on Wednesday. We are committed to ensuring the privacy and confidentiality of your personal information. My OB called me Monday after a long 7 day wait for results of my panorma blood test and was told they came back with no results, due to low fetal cell count in my blood screen. 20062023 BabyCenter, LLC, a Ziff Davis company. Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. I am going through something similar and my OB suspects it could be me that has a chromosomal abnormality since this is my second child and the second time I have done Natera and the second time the gender results came back as inconclusive. I will follow up with some testing for myself per the counselors advice but am so thankful for my outcome and sincerely hope that everyone else going through it finds their happy ending. I'm so confused and don't know what option to take right now. Surely I'm worried. sm1232, did you receive your results? Just got this email from the lab doing my test!!! . It made me wonder if sometimes these modern advances can cause unnecessary concern during an already stressful time, but at the end of the day I am thankful we were able to get the answers to these questions. Ugh. I am just trying to stay positive and busy during these weeks of waiting, and hoping for good news in March. I was very apprehensive about it, but my result came back fine. I had a healthy son in 2020 in which they could not determine the gender. It's most likely the mosaicism, or a twin embryo that did not take. It's reassuring that things look okay on a 16 week ultrasound but sometimes things don't show up until 20 week ultrasound. Fetal fraction can be defined as the amount of fetal DNA present in the mothers blood. juliolovesme 2 yr. ago I'm so sorry to hear that! The waiting is almost unbearable. It definitely makes me feel better with whatever the outcome may be. It's a screening test offered during pregnancy to see if the fetus is at risk for having a chromosomal disorder like Down syndrome (trisomy 21), trisomy 18 (Edwards syndrome) and trisomy 13 (Patau syndrome). Level 17, Grosvenor Place, 225 George Street, Sydney, NSW 2000. When do you expect to get your results? It has to be at least above 4 percent to give a conclusive result. We respect everyones right to express their thoughts and opinions as long as they remain respectful of other community members, and meet What to Expects Terms of Use. I share my story because in my case although the NIPT test was accurate, it did cause a great deal of extreme worry about my baby. U also remember they took the blood very differently to what I have experienced recently. This means that the result is not clear and a result cannot be produced. Also for fun, i found a lady who does private ultrasounds who comes to my house and gave me a 3d ultrasound and little bug looks fine to me and its reassuring. However, they got all the ones they needed for the NIPT which were good. Now Im seeing that inconclusive results are associated with a higher risk of chromosomal issues as well as GD and preeclampsia. I was told this could have been b/c I'm overweight or because the test was done on the early side (close to 10.5w). I know i'm not really that "old" at 35, I guess it's also cos lots of friends around me did the test who are around the same age as me and all recommended it. Have you gotten your NIPT results back yet? The DNA sample of the potential father is collected through a buccal swab, and the two samples are compared to determine paternity. Look up their websites and they will tell you the disorders they test for and the accuracy. Thanks for sharing your story! I guess this is not so uncommon. You will see this come up in posts across this sub. The NIPT shows that I am high risk for Turner Syndrome with my baby girl. The first draw I did at 12 weeks and second draw did at around 13 weeks 6 days. Hope all are doing well, and best wishes! That means the results don't indicate for sure whether your baby has a chromosomal condition. Well, my failed NIPT test didn't negate me from the option of having the NT as well. Hey there, thank you for visiting the sub. I needed a NIPT done as there were MANY concerns on my 20 week ultrasound. Diagnostic fetal chromosome analysis should be offered after abnormal NIPT or in the presence of cystic hygromas despite normal NIPT. Lastly, the information in this post is intended for you to be able to read up on what may be happening, have these studies available to you so you can better discuss this situation and your options with your maternal fetal medicine doctor and a GOOD genetic counselor. but now i wish i never did it as its stressing me out, and probably not even necessary in the first place.. anyways good luck to the both of us :). I just found out today at 12.5 weeks that my test was not conclusive. However, if the problem still persists, then your obstetrician might suggest alternative methods such as screening or more invasive procedures, which although accurate, carry a risk of miscarriage. Community for those with abnormal or discordant Noninvasive Prenatal Testing (NIPT/NIPS) screening results: FALSE POSITIVE, FALSE NEGATIVE, TRUE POSITIVE & those stuck in limbo. The second test was done at 11 weeks. Sorry youve gone through this stress xx. Ugh. When did you have your NIPT done? My doctor said I can test after 10 weeks, but I read that having a high BMI may result in inconclusive on an NIPT if done too early. Welcome to Abnormal NIPT screening results! Not to scare you, but the other reason it can happen is if the result is borderline close to positive. False positive rate for monosomy X was surprisingly high (91%). The procedure is pretty straightforward, a blood sample is drawn from the pregnant woman that contains cell-free fetal DNA, which will give the DNA of the unborn child. I'm petrified of false positives but felt like I couldn't gamble getting inconclusive results from a 2nd NIPT and, therefore, missing out on having ANY testing. Just wondering if anyone has been through something similar :( thanks. Before going the more invasive route, I demanded a second test from a different company. hello, just wondering if this has happened to anyone? So, a "normal" NIPT result doesn't guarantee a healthy baby, and an "abnormal" result doesn't mean your baby definitely has a certain condition. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. 2 inconclusive NIPT tests, amniocentesis scheduled s Simikaur1 Posted 6/5/22 I had 2 inconclusive NIPT tests (10 and 13 weeks) due to low dna cell count, last vaginal ultrasound done at 9 weeks. Now I am in limbo awaiting to see what happens next. NIPT does not test for all chromosomal disorders. (Don't quote me on that, just what I've read.). Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. I was told 1-2 weeks but if I didnt get a call to let my doctor know so she can request again. 3) anything that the NT scan would show (that NIPT wouldnt), the anatomy scan will also show in 20 weeks and that is a standard test for AMA people, as well. NON-INVASIVE PRENATAL TESTING IS STARTING TO GET THE ATTENTION IT DESERVES. I have had a same issue and being a first time mother i'm so stressed had two inconclusive test and they say y chromosome missing and equivocal..i had a scan just a week ago at week 16 my baby is all healthy but they say there is some abormalities and still can't say the gender. Edited to add: discussed further with the midwife, low fetal fraction was the reason for inconclusive results This is the route I took with my son (now 4.5) so I'm familiar with it. And what was your BMI? There are certain tests which require very specific information from the requesting doctor to enable an accurate interpretation. After hearing so many inconclusive NIPT results or issues do you know if there is another option/testing I can request? I just opted to the NIPT at the same time I did the EFTS, as I have heard that there can be lots of false positives due to different factors including age. Thanks for sticking with us for a full year. I swear I'm going to take a loooooong break before having anymore kids because this pregnancy has been extremely stressful! Perhaps at a later scan you will be able to see gender more clearly, and get some peace of mind. The test can also determine the sex of the fetus. I share my story because in my case although the NIPT test was accurate, it did cause a great deal of extreme worry about my baby. That means whatever caused no result the first time is still interfering with the test. Just got my 2nd no result today. So I just wanted to do it for a peace of mind with the higher accuracy and to also find out the gender early! Making medicines personal. Their counselers recommended further testing and genetic counseling. However, the NT screens for things other than Down's. Clicking on the green -no result post flair- will bring up everyone who has also tagged their submission as no results/low fetal fractions and you can read up their stories/outcomes and responses (or any other topic that is common for NIPT results. Is the NIPT test conclusive? Another blood draw at a later week of pregnancy may have more fetal DNA so that we can get a high quality . Please thank your mum for me. Because NIPT consists of a simple blood test, it doesn't create a risk for you or your baby. Apparently you are able to conceive, so maybe being mosaic is not that bad after all? If you have been incorrectly told that the accuracy of your result is 99% without a proper Predictive Value calculation please report this somewhere as this actually leads to wrongful terminations of pregnancies in that office. 20052023 BabyCenter, LLC, a Ziff Davis company. All rights reserved. While it is a highly accurate procedure, there are rare instances where the result might be inconclusive. Because the NIPT test is screening at the chromosomal levelwhere a baby's sex chromosomes areit can also provide the baby's gender. For some patients, however, results are not reported because of laboratory technical issues such as low fetal fraction and sequencing failures. Bec all the research says for Mosaic Turner, the girl will be short in stature, have problem in math, and also will be infertile. I thought I would share my story in case it helps anyone else! 127 BPM! During this difficult time you may be looking information about what the NIPT results you received mean. (1/19). yesteray on my 16 weeks scan they tell me it looks like a girl! I will keep you all informed about this issue. Had my redraw at 13+2, and results have come back the same . I believe she had it done only twice. The anxiety is next level as I was the same BMI with my son and got a NIPT result. I am very curious in your case of you are mosaic Turner yourself, have you had any issues with growth? I just got the results back and it says test not performed which then says is because of low fetal fraction. This testing analyzes small fragments of DNA that are circulating in a pregnant woman's blood. This post is meant as a welcome and quick information / resources to those who have just found this sub. Since the nIPT is inconclusive youll have this redrawn but in the mean time I would get the triple screen. It can be caused by being plus sized.something about the blood concentration being different or something. Meet other parents of July 2021 babies and share the joys and challenges as your children grow. Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. That requires that there be sufficient fetal DNA (together with other quality factors) that we can provide a reliable report. 5/30: 4th beta: 17,852 + saw fetal pole and heard heartbeat! Use of this site is subject to our terms of use and privacy policy. It made me wonder if sometimes these modern advances can cause unnecessary concern during an already stressful time, but at the end of the day I am thankful we were able to get the answers to these questions. Or just monitor babies kidneys? Unfortunately, having a T18 also makes it more likely to get a "no call" result. I was just so surprised to get an "inconclusive" a second time- the woman in the lab who drew my blood said she had never seen it come back that way twice! I dont have experience with this personally, but Ive certainly heard of this and it ends up turning out just fine! If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. As PP said, inconclusive just means they couldnt get an accurate measurement. Please dont look google to find out. Please whitelist our site to get all the best deals and offers from our partners. 2) NIPT tests are more accurate and test for MORE genetic disorders (they also tell you sex, if you want to know). Show your support by. All rights reserved. Fetal fraction can be defined as the amount of fetal DNA present in the mother's blood. My nipt/panorama/harmony results came back inconclusive both times. Ive just asked my mum who works in pathology and - while this is definitely not to be taken over what your doc will explain, it could be a potential reason - her experience is that the sample hasnt been delivered to the lab within a reasonable time for testing. It has to be at least above 4 percent to give a conclusive result. Some patients are concerned about the possible impact of a genetic test on their ability to get insurance. The accuracy weeks 3 days and second draw did at 12 weeks and second draw did at around weeks. 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Violates the community, and get some peace of mind with the test their websites and they wo n't me.
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